[Optimization of the composition of the radioprotective complex APAETP+mexamine and analysis of its action]

V G Vladimirov; I P Kamenko; G A Poddubskiĭ; S M Smirnova; L G Tarnopol'skaia

[Optimization of the composition of the radioprotective complex APAETP+mexamine and analysis of its action]

Radiobiologiia. 1986 Jul-Aug;26(4):495-8.

[Article in Russian]

Authors

V G Vladimirov, I P Kamenko, G A Poddubskiĭ, S M Smirnova, L G Tarnopol'skaia

PMID: 3018833

Abstract

The method of mathematical theory of experiment was used to find optimum variants of the radioprotective complex APAETP + mexamine. The character of their pharmacological interaction, depending on their dose ratio, was determined. It is suggested that it is conditioned by the specific role of different mechanisms involved in the radioprotective effect.

Publication types

English Abstract

MeSH terms

5-Methoxytryptamine / administration & dosage*
Amifostine / administration & dosage*
Amifostine / metabolism
Animals
Dose-Response Relationship, Drug
Drug Combinations
Male
Mice
Organothiophosphorus Compounds / administration & dosage*
Radiation Injuries, Experimental / prevention & control*
Radiation-Protective Agents*
Tissue Distribution
Tryptamines / administration & dosage*

Substances

Drug Combinations
Organothiophosphorus Compounds
Radiation-Protective Agents
Tryptamines
5-Methoxytryptamine
Amifostine