Chronic pulmonary complications associated with toxic epidermal necrolysis: A case report and literature review

Exp Ther Med. 2018 Sep;16(3):2027-2031. doi: 10.3892/etm.2018.6357. Epub 2018 Jun 27.

Abstract

Patients with toxic epidermal necrolysis (TEN) are known to experience various complications. Although pulmonary complications are commonly observed, they typically manifest in an acute form. By contrast, chronic complications are quite rare, and little is known with regard to their incidences or clinical manifestations. The present study reports the case of a 29-year-old female patient who suffered from TEN. At the onset of the disease, the patient exhibited no pulmonary impairment; however, 1 month after recovering from TEN, the patient developed severe obstruction and a mild diffusion defect. A diagnosis of bronchiolitis obliterans was determined, and the patient was treated with antibiotics, inhaled corticosteroids, anticholinergic agents, and bronchodilators. At the last follow-up, the patient was alive, but with a stable airway obstruction.

Keywords: chronic pulmonary complications; toxic epidermal necrolysis.