A review of application of stem cell therapy in the management of congenital heart disease

J Matern Fetal Neonatal Med. 2020 May;33(9):1607-1615. doi: 10.1080/14767058.2018.1520829. Epub 2018 Oct 1.

Abstract

Research on stem cells has been rapidly growing with impressive breakthroughs. Although merely a few of the laboratory researches have successfully transited to the clinical trial phase, the application of stem cells as a therapeutic option for some currently incapacitating diseases hold fascinating potentials. This review emphasis the various opportunities for the application of stem cell in the treatment of fetal diseases. First, we provide a brief commentary on the common stem cell strategy used in the treatment of congenital anomalies, thereafter we discuss how stem cell is being used in the management of some fetal disorders.

Keywords: Cell therapy; fetal disease; in utero hematopoietic transplantation; stem cell.

Publication types

  • Review

MeSH terms

  • Animals
  • Child
  • Disease Models, Animal
  • Female
  • Fetal Diseases / surgery*
  • Fetoscopy
  • Heart Defects, Congenital / classification
  • Heart Defects, Congenital / surgery*
  • Humans
  • Pregnancy
  • Stem Cell Transplantation / methods*
  • Tissue Engineering / methods