pH-sensitive and biocompatible quercetin-loaded GO-PEA-HA carrier improved antitumour efficiency and specificity

Abstract

A novel drug carrier was designed based on a new biomaterial, that is, graphene oxide (GO), to improve the efficiency and specificity of anticancer drug. In this study, GO was successively modified with polyetheramine (PEA) and hyaluronic acid (HA). The carrier was utilized to load an antitumor component, that is, quercetin (Que), which was derived from traditional Chinese medicine, namely the pagoda tree flower bud. This drug delivery system (DDS) exhibited pH sensibility under subacid condition and good biocompatibility even when GO concentration reached 350 μg/mL. Moreover, the antitumor efficacy was doubly improved and more long-acting compared with Que alone. Results show that the GO-based material has potential clinical applications for antitumor drug delivery.

Keywords: Quercetin; anticancer drug delivery; graphene oxide; pH-sensitive.