Detection of East/Central/South African genotype Chikungunya virus during an outbreak in a southeastern state of Brazil

Epidemiol Infect. 2018 Dec;146(16):2056-2058. doi: 10.1017/S0950268818002467. Epub 2018 Sep 5.

Abstract

Chikungunya virus (CHIKV) is an arbovirus transmitted by Aedes mosquitoes that was first identified in Brazil in 2014. It causes a febrile illness characterised by severe arthralgia and rash. Our group investigated a suspected CHIKV outbreak in Governador Valadares, state of Minas Gerais, Brazil and from 25 acute-phase patients, 10 had qRT-PCR positive sera samples and had E1 partial sequence amplified and Sanger sequenced. Samples were identified as East/Central/South African (ECSA) genotype by phylogenetic analysis and clustered with CHIKV sequences isolated in the neighbour state of Bahia. Our findings confirm previous predictions that ECSA genotype would spread through northeast and southeast of Brazil.

Keywords: Brazil; Chikungunya virus; genotype.

MeSH terms

  • Brazil / epidemiology
  • Chikungunya Fever / epidemiology*
  • Chikungunya Fever / virology*
  • Chikungunya virus / classification*
  • Chikungunya virus / genetics
  • Chikungunya virus / isolation & purification*
  • Cluster Analysis
  • Disease Outbreaks*
  • Genotype*
  • Humans
  • Phylogeny
  • Real-Time Polymerase Chain Reaction
  • Sequence Analysis, DNA
  • Serum / virology
  • Viral Envelope Proteins / genetics

Substances

  • Viral Envelope Proteins