The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid-Coated Gold Nanorods

Su Pan; Hongcun Xing; Xuqi Fu; Hongmei Yu; Zhaogang Yang; Yudan Yang; Wei Sun

doi:10.1177/1559325818789841

The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid-Coated Gold Nanorods

Dose Response. 2018 Aug 29;16(3):1559325818789841. doi: 10.1177/1559325818789841. eCollection 2018 Jul-Sep.

Authors

Su Pan^{1

2}, Hongcun Xing^{3

2}, Xuqi Fu³, Hongmei Yu⁴, Zhaogang Yang⁵, Yudan Yang⁴, Wei Sun⁶

Affiliations

¹ Department of Orthopedics, The Second Hospital of Jilin University, Changchun, Jilin, China.
² These authors contributed equally to this study.
³ College of Life Sciences, Jilin University, Changchun, Jilin, China.
⁴ China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
⁵ Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA.
⁶ Department of Molecular Biology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin, China.

Abstract

Background: Polyacrylic acid (PAA)-coated gold nanorods (GNRs) were prepared in this research, and then the structure, stability, temperature increment efficiency, and biocompatibility of GNRs@PAA were detected.

Methods: It was demonstrated that GNRs@PAA coupled with an 808 nm laser had superior efficiency of hyperthermia therapy for MG63 human osteosarcoma cell.

Results: The mechanism of photothermal therapy of GNRs@PAA was explored, and it was proved that damaged cell membrane and DNA integration caused cell apoptosis and death, and the cell apoptosis rate had been obviously promoted by in vitro photothermal therapy which exhibited time-dose dependence.

Conclusion: The results demonstrated that the GNRs@PAA could be a promising candidate for phototherapeutic applications in human osteosarcoma.

Keywords: apoptosis; metal nanostructures; osteosarcoma; photothermal therapy; time–dose dependent.