Typhoid fever with isolated left lateral rectus palsy

BMJ Case Rep. 2018 Sep 4:2018:bcr2018225746. doi: 10.1136/bcr-2018-225746.

Abstract

A 17-year-old young woman presented to Patan Hospital, Kathmandu, Nepal, with high-grade fever and headache for 4 days and non-projectile vomiting for 1 day. She also had blurred vision with dizziness on and off. There was no abnormal physical finding. Enteric fever was suspected, and she was empirically started on azithromycin (20 mg/kg) for 7 days. She became afebrile after 2 days and was followed up in 7 days with diplopia since 5 days. At this time, the blood culture was positive for Salmonella serovar typhi. On examination, there was isolated left lateral rectus palsy which accounted for her diplopia. Methylprednisolone (1 mg/kg) was prescribed which was tapered over 1 month and gradually her diplopia subsided. We hypothesise that vasculitic change in the blood vessel supplying the left abducens nerve could be causing the diplopia.

Keywords: cranial nerves; infection (gastroenterology); neuroopthalmology; tropical medicine (infectious disease).

Publication types

  • Case Reports

MeSH terms

  • Abducens Nerve Diseases / complications
  • Abducens Nerve Diseases / drug therapy
  • Abducens Nerve Diseases / microbiology*
  • Adolescent
  • Anti-Bacterial Agents / therapeutic use
  • Anti-Inflammatory Agents / therapeutic use
  • Azithromycin / therapeutic use
  • Diplopia / drug therapy
  • Diplopia / microbiology
  • Female
  • Humans
  • Methylprednisolone / therapeutic use
  • Neuroprotective Agents / therapeutic use
  • Typhoid Fever / complications*
  • Typhoid Fever / diagnosis
  • Typhoid Fever / drug therapy

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents
  • Neuroprotective Agents
  • Azithromycin
  • Methylprednisolone