Three-vessel coronary artery disease may predict changes in biochemical brain injury markers after off-pump coronary artery bypass grafting

J Zhejiang Univ Sci B. 2018;19(9):735-738. doi: 10.1631/jzus.B1700553.

Abstract

Neurological injury is a frequent and important complication of coronary artery bypass grafting (CABG). Several risk factors for this type of sequela have been identified, among them aortic arch atherosclerosis. Our previous study indicated that atherosclerotic burden in coronary arteries may likewise predict postoperative neurological complications (Pawliszak et al., 2016b). We assessed the severity of this condition by using the SYNTAX score calculator. However, diagnosing angiographic three-vessel coronary artery disease (3VD) could be an even simpler method of achieving this goal.

Keywords: Cardiac surgery; Coronary artery disease; Glial fibrillary acidic protein; Neuroserpin; Phosphorylated axonal neurofilament subunit H.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Coronary Angiography
  • Coronary Artery Bypass, Off-Pump / adverse effects*
  • Coronary Artery Disease / diagnostic imaging
  • Coronary Artery Disease / surgery*
  • Female
  • Glial Fibrillary Acidic Protein / blood*
  • Humans
  • Male
  • Middle Aged
  • Neurofilament Proteins / blood*
  • Neuropeptides / blood*
  • Neuroserpin
  • Phosphorylation
  • Prospective Studies
  • Serpins / blood*

Substances

  • GFAP protein, human
  • Glial Fibrillary Acidic Protein
  • Neurofilament Proteins
  • Neuropeptides
  • Serpins
  • neurofilament protein H