The Mitochondrial Na+/Ca2+ Exchanger is Necessary but Not Sufficient for Ca2+ Homeostasis and Viability

Timon Cheng-Yi Liu; Xiao-Ming Tang; Rui Duan; Lei Ma; Ling Zhu; Quan-Guang Zhang

doi:10.1007/978-3-319-91287-5_45

The Mitochondrial Na⁺/Ca²⁺ Exchanger is Necessary but Not Sufficient for Ca²⁺ Homeostasis and Viability

Adv Exp Med Biol. 2018:1072:281-285. doi: 10.1007/978-3-319-91287-5_45.

Authors

Timon Cheng-Yi Liu¹, Xiao-Ming Tang², Rui Duan², Lei Ma³, Ling Zhu², Quan-Guang Zhang²

Affiliations

¹ Laboratory of Laser Sports Medicine, South China Normal University, Guangzhou, China. liutcy@scnu.edu.cn.
² Laboratory of Laser Sports Medicine, South China Normal University, Guangzhou, China.
³ School of Electronic Information, Nantong University, Nantong, China.

PMID: 30178359
DOI: 10.1007/978-3-319-91287-5_45

Abstract

Luongo et al. found that the mitochondrial Na⁺/Ca²⁺ exchanger (NCLX) was essential for Ca²⁺ homeostasis and viability. Here, we re-analyze their data in terms of fractal self-similarity and quantitative difference (QD). We calculated the 7-dimension data from NCLX conditional loss-of-function mouse models, and the 9-dimension data from NCLX overexpression (NCLX-Tg) models.

Results: The 9-dimension data of the NCLX-Tg and its tTA control were partially self-similar to each other, while the 7-dimension data in NCLX knockout models were not.

Conclusion: The NCLX may be necessary but is not sufficient for Ca²⁺ homeostasis and viability.

MeSH terms

Algorithms
Animals
Calcium / metabolism*
Calcium Signaling / physiology
Cell Survival / physiology*
Homeostasis / physiology*
Mice
Mitochondria / metabolism
Models, Theoretical*
Sodium-Calcium Exchanger / metabolism*

Substances

Sodium-Calcium Exchanger
sodium-calcium exchanger 1
Calcium