Construction of a targeted photodynamic nanotheranostic agent using upconversion nanoparticles coated with an ultrathin silica layer

Zihong Yue; Tongtong Hong; Xinyue Song; Zonghua Wang

doi:10.1039/c8cc05121f

Construction of a targeted photodynamic nanotheranostic agent using upconversion nanoparticles coated with an ultrathin silica layer

Chem Commun (Camb). 2018 Sep 25;54(75):10618-10621. doi: 10.1039/c8cc05121f. Epub 2018 Sep 4.

Authors

Zihong Yue¹, Tongtong Hong¹, Xinyue Song², Zonghua Wang³

Affiliations

¹ College of Chemistry and Chemical Engineering, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Qingdao University, Shandong 266071, P. R. China. wangzonghua@qdu.edu.cn and Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, Linyi University, Linyi 276005, P. R. China. songxinyue428@163.com.
² Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, Linyi University, Linyi 276005, P. R. China. songxinyue428@163.com.
³ College of Chemistry and Chemical Engineering, Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials, Qingdao University, Shandong 266071, P. R. China. wangzonghua@qdu.edu.cn.

PMID: 30177988
DOI: 10.1039/c8cc05121f

Abstract

Two-activator codoped UCNPs served as energy donors and photosensitizers entrapped in an ultrathin silica layer served as energy acceptors to establish LRET-based photodynamic therapy with the advantages of shortened donor-to-acceptor distance and enhanced LRET efficiency. The exterior PEG-FA ligand further enhanced the biocompatibility and targetability to cancer cells and the tumor section.