Matrices, scaffolds, and carriers for protein and molecule delivery in peripheral nerve regeneration

Kasra Tajdaran; Katelyn Chan; Tessa Gordon; Gregory H Borschel

doi:10.1016/j.expneurol.2018.08.014

Matrices, scaffolds, and carriers for protein and molecule delivery in peripheral nerve regeneration

Exp Neurol. 2019 Sep:319:112817. doi: 10.1016/j.expneurol.2018.08.014. Epub 2018 Aug 31.

Authors

Kasra Tajdaran¹, Katelyn Chan², Tessa Gordon³, Gregory H Borschel⁴

Affiliations

¹ Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G1X8, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada. Electronic address: kasra.tajdaran@mail.utoronto.ca.
² Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G1X8, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
³ Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G1X8, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; Program in Neuroscience, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
⁴ Division of Plastic and Reconstructive Surgery, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario M5G1X8, Canada; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Program in Neuroscience, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.

PMID: 30176220
DOI: 10.1016/j.expneurol.2018.08.014

Abstract

Local application of exogenous agents with neurotrophic properties enhances the regenerative capacity of injured neurons, especially following reconstructions of long nerve gaps and delayed nerve repairs. Recent advances in biomaterials and biomedical engineering have provided options for the sustained and controlled release of macromolecules to the peripheral nerve. Here, we review five methods for delivering macromolecules to the peripheral nerve including mini-osmotic pumps, hydrogel-based delivery systems, nerve guidance conduits, electrospun fibers, and nerve wraps. In addition to controlling the release of bioactive macromolecules, the ease of clinical use and versatility in implantation at a variety of "real-world" anatomical locations are key factors in designing an ideal delivery system. The incorporation of both mechanical and biological cues into such devices also helps optimize these systems.

Keywords: Biomaterial; Controlled release; Cytokine delivery; GDNF; Local drug delivery; Nerve injury; Nerve regeneration; Regenerative medicine.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Biocompatible Materials
Drug Carriers
Drug Delivery Systems
Humans
Nerve Regeneration*
Peripheral Nerves / growth & development*
Peripheral Nerves / physiology
Tissue Scaffolds*

Substances

Biocompatible Materials
Drug Carriers