Data on in vivo antioxidant, hypolipidemic and hepatoprotective potential of Thaumatococcus daniellii (Benn.) Benth leaves

Shalom Nwodo Chinedu; Franklyn Nonso Iheagwam; Boluwatife Taiwo Makinde; Babajide Oladipo Thorpe; Opeyemi Christianah Emiloju

doi:10.1016/j.dib.2018.08.016

Data on in vivo antioxidant, hypolipidemic and hepatoprotective potential of Thaumatococcus daniellii (Benn.) Benth leaves

Data Brief. 2018 Aug 10:20:364-370. doi: 10.1016/j.dib.2018.08.016. eCollection 2018 Oct.

Authors

Shalom Nwodo Chinedu^{1

2}, Franklyn Nonso Iheagwam^{1

2}, Boluwatife Taiwo Makinde¹, Babajide Oladipo Thorpe¹, Opeyemi Christianah Emiloju^{1

2}

Affiliations

¹ Department of Biochemistry, College of Science and Technology, Covenant University, P.M.B. 1023, Canaanland, Ota, Ogun State, Nigeria.
² Covenant University Public Health and Wellness Research Cluster (CUPHWERC), Covenant University, P.M.B. 1023, Canaanland, Ota, Ogun State, Nigeria.

Abstract

This data article reports on the in vivo biochemical activity of ethanolic extract of Thaumatococcus daniellii (Benn.) Benth leaves (ETD) in male Wistar rats at an oral dose of 500-1500 mg/kg daily for 14 days. Control groups were administered distilled water and Vitamin C (10 mg/kg; b.wt). Indices of oxidative stress, dyslipidemia, liver injury and liver pathology were estimated in the plasma and organs after the investigation period. Oral treatment with ETD increased organ superoxide dismutase (SOD) activity, renal reduced glutathione (GSH) and plasma high density lipoprotein (HDL) concentrations while reducing plasma alanine transaminase (ALT) activity, plasma cholesterol (CHOL), bilirubin (DBIL) and organ malondialdehyde (MDA) concentrations (P<0.05). Data was supported by histological report showing no pathologic abnormality. This data indicate ethanolic extract of T. daniellii leaves shows antioxidant, hypolipidemic and hepatoprotective potential.

Keywords: Antioxidant; Hypolipidemic; Liver injury; Oxidative stress; Thaumatococcus daniellii; in vivo.