DNA mismatch repair preferentially safeguards actively transcribed genes

DNA Repair (Amst). 2018 Nov:71:82-86. doi: 10.1016/j.dnarep.2018.08.010. Epub 2018 Aug 23.

Abstract

DNA mismatch repair (MMR) is an evolutionally conserved genome maintenance pathway and is well known for its role in maintaining replication fidelity by correcting biosynthetic errors generated during DNA replication. However, recent studies have shown that MMR preferentially protects actively transcribed genes from mutation during both DNA replication and transcription. This review describes the recent discoveries in this area. Potential mechanisms by which MMR safeguards actively transcribed genes are also discussed.

Keywords: Actively-transcribed genes; H3K36me3; MSH6; Mutation frequency; Replication timing; Transcription-coupled repair.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • DNA / metabolism
  • DNA Mismatch Repair*
  • DNA-Binding Proteins / metabolism
  • Eukaryota / genetics
  • Eukaryota / metabolism
  • Humans
  • Mutation
  • Transcription, Genetic*

Substances

  • DNA-Binding Proteins
  • G-T mismatch-binding protein
  • DNA