Oxyhemoglobin changes in the prefrontal cortex in response to cognitive tasks: a systematic review

Int J Neurosci. 2019 Feb;129(2):195-203. doi: 10.1080/00207454.2018.1518906. Epub 2018 Oct 31.

Abstract

Purpose of the study: the aim of this study was to synthesize PFC fNIRS outcomes on the effects of cognitive tasks compared to resting/baseline tasks in healthy adults from studies utilizing a pre/post design.

Material and methods: original research studies were searched from seven databases (MEDLINE, EMBASE, CENTRAL, CINAHL, SCOPUS, PEDro and PubMed). Subsequently, two independent reviewers screened the titles and abstracts followed by full-text reviews to assess the studies' eligibility.

Results: eleven studies met the inclusion criteria and had data abstracted and quality assessed. Methodology varied considerably and yet cognitive tasks resulted in the ΔO2Hb increasing in 8 of the 11 and ΔHHb decreasing in 8 of 8 studies that reported this outcome. The cognitive tasks from 10 of the 11 studies were classified as "Working Memory" and "Verbal Fluency Tasks".

Conclusions: although, the data comparison was challenging provided the heterogeneity in methodology, the results across studies were similar.

Keywords: Prefrontal cortex; cognitive task; healthy subjects; near infrared spectroscopy; oxyhemoglobins.

Publication types

  • Systematic Review

MeSH terms

  • Cognition / physiology*
  • Functional Neuroimaging
  • Humans
  • Memory, Short-Term / physiology
  • Neuropsychological Tests
  • Oxyhemoglobins / metabolism*
  • Prefrontal Cortex / metabolism*
  • Spectroscopy, Near-Infrared

Substances

  • Oxyhemoglobins