The effects of a muscarinic receptor 1 gene variant on cortical thickness and surface area in schizophrenia

Sean P Carruthers; Caroline T Gurvich; Vanessa L Cropley; Christos Pantelis; Chad Bousman; Rhoshel K Lenroot; Jason M Bruggemann; Thomas Weickert; Australian Schizophrenia Research Bank; Susan L Rossell

doi:10.1016/j.pscychresns.2018.08.014

The effects of a muscarinic receptor 1 gene variant on cortical thickness and surface area in schizophrenia

Psychiatry Res Neuroimaging. 2018 Oct 30:280:62-64. doi: 10.1016/j.pscychresns.2018.08.014. Epub 2018 Aug 24.

Affiliations

¹ Centre for Mental Health, Faculty of Health, Arts and Design, Swinburne University of Technology, Victoria 3122, Australia. Electronic address: scarruthers@swin.edu.au.
² Monash Alfred Psychiatry research centre (MAPrc), Monash University Central Clinical School and The Alfred Hospital, Melbourne 3004, Australia.
³ Centre for Mental Health, Faculty of Health, Arts and Design, Swinburne University of Technology, Victoria 3122, Australia; Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia; Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia.
⁴ Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia; Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, Victoria 3052, Australia; Cooperative Research Centre (CRC) for Mental Health, 161 Barry Street, Carlton, Victoria 3053, Australia; Centre for Neural Engineering, The University of Melbourne, Carlton, VIC, Australia.
⁵ Department of Psychiatry, The University of Melbourne, Parkville, Victoria 3052, Australia; Cooperative Research Centre (CRC) for Mental Health, 161 Barry Street, Carlton, Victoria 3053, Australia; Departments of Medical Genetics, Psychiatry, and Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada.
⁶ School of Psychiatry, University of New South Wales, Sydney, NSW, Australia.
⁷ School of Psychiatry, University of New South Wales, Sydney, NSW, Australia; Neuroscience Research Australia, Randwick, Sydney, NSW, Australia.
⁸ Schizophrenia Research Institute, 405 Liverpool Street, Darlinghurst, Sydney, NSW 2010, Australia.
⁹ Centre for Mental Health, Faculty of Health, Arts and Design, Swinburne University of Technology, Victoria 3122, Australia; Psychiatry, St Vincent's Hospital, Melbourne, Victoria 3065, Australia.

PMID: 30173002
DOI: 10.1016/j.pscychresns.2018.08.014

Abstract

Individuals with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism (rs2067477) within the cholinergic muscarinic M1 receptor gene have been reported to perform less well on the Wisconsin Card Sorting Test and demonstrate reduced grey matter volume in the right precentral gyrus. We investigated if rs2067477 genotype variation influenced cortical thickness and cortical surface area in a sample of 176 schizophrenia/schizoaffective disorder patients using FreeSurfer. We were unable to detect any significant changes to either surface-based measure of brain structure across genotype. Future studies should expand the focus and include SNPs that are in linkage disequilibrium with rs2067477.

Keywords: M1; Schizoaffective disorder; Surface-based morphometry.

MeSH terms

Adolescent
Adult
Cerebral Cortex / diagnostic imaging*
Female
Genetic Variation / genetics*
Gray Matter / diagnostic imaging
Humans
Male
Middle Aged
Organ Size
Polymorphism, Single Nucleotide / genetics
Receptor, Muscarinic M1 / genetics*
Schizophrenia / diagnostic imaging*
Schizophrenia / genetics*
Young Adult

Substances

Receptor, Muscarinic M1