Prostate-specific antigen (PSA) is a biomarker for the diagnosis and management of prostate cancer and involved in the development of prostate cancer and/or its progression from the localized to the metastatic stage. This review presents an overview of the roles of PSA in promoting the progression and metastasis of human prostate cancer and its underlying mechanisms, including its serine protease activity, interaction with the cellular membrane receptor, and suppression of specific immune responsiveness, and also points out some of the key problems to be solved.
前列腺特异性抗原（PSA）是1个前列腺癌诊断和管理生物标志物，并对前列腺癌的发展和/或前列腺原位癌向转移癌的进展有一定作用。本文综述了PSA在人前列腺癌发展中促进前列腺癌发展和转移等的作用，阐述了PSA对前列腺癌发展和转移影响的可能机制，包括丝氨酸蛋白酶活性、以无酶活性形式与细胞膜受体结合发挥作用和抑制免疫功能等，并指出亟待解决的关键问题。.
Keywords: cellular membrane receptor; immunosuppression; metastasis; progression; prostate cancer; prostate-specific antigen; serine protease activity.