Cytokines as therapeutic agents and targets in heart disease

Arita Dubnika; Martin A C Manoukian; M Rezaa Mohammadi; Mansi Bharat Parekh; Abhijit Achyut Gurjarpadhye; Mohammed Inayathullah; Viktors Dubniks; Jonathan R T Lakey; Jayakumar Rajadas

doi:10.1016/j.cytogfr.2018.08.003

Cytokines as therapeutic agents and targets in heart disease

Cytokine Growth Factor Rev. 2018 Oct:43:54-68. doi: 10.1016/j.cytogfr.2018.08.003. Epub 2018 Aug 16.

Authors

Arita Dubnika¹, Martin A C Manoukian², M Rezaa Mohammadi³, Mansi Bharat Parekh³, Abhijit Achyut Gurjarpadhye³, Mohammed Inayathullah³, Viktors Dubniks⁴, Jonathan R T Lakey⁵, Jayakumar Rajadas⁶

Affiliations

¹ Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Palo Alto, CA 94304, USA; Riga Technical University, Faculty of Materials Science and Applied Chemistry, Institute of General Chemical Engineering, Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Pulka str. 3/3, Riga, LV-1007, Latvia. Electronic address: arita.dubnika@rtu.lv.
² Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Palo Alto, CA 94304, USA; University of California, Davis School of Medicine, 4610 X Street, Sacramento, CA, 95817, USA.
³ Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
⁴ Riga Technical University, Faculty of Materials Science and Applied Chemistry, Institute of General Chemical Engineering, Rudolfs Cimdins Riga Biomaterials Innovations and Development Centre, Pulka str. 3/3, Riga, LV-1007, Latvia.
⁵ Departments of Surgery and Biomedical Engineering, University of California Irvine, Irvine, CA 92697, United States.
⁶ Biomaterials and Advanced Drug Delivery Laboratory, Stanford University School of Medicine, Palo Alto, CA 94304, USA. Electronic address: jayraja@stanford.edu.

PMID: 30170892
DOI: 10.1016/j.cytogfr.2018.08.003

Abstract

Cytokine therapies have emerged during the past decade as promising noninvasive treatments for heart disease. In general, current drug treatments are directed towards symptom control and prevention of disease progression; however, many agents also produce cause side effects that alter quality of life. Cytokine based therapies have the potential to reduce post-infarct heart failure and chronic ischemia by stimulating the proliferation and differentiation of endothelial cells and bone marrow hematopoietic stem cells and mobilizing these cells toward ischemic tissue. In turn, these mobilized cell populations contribute to myocardial regeneration. In contrast, over-expression of several cytokines has been linked to a variety of heart diseases; thus, therapies targeting and monitoring these cytokines are of great interest. Here we summarize results from clinical studies on cytokines as therapeutic agents or therapeutic targets in the treatment for heart disease as well as cytokines involved in the evolution of heart disease.

Keywords: Cytokine therapies; Ischemia; Myocardial infarction; Therapeutic cytokines.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cytokines* / immunology
Cytokines* / therapeutic use
Heart Diseases* / drug therapy
Heart Diseases* / immunology
Humans

Substances

Cytokines