Pleural malignant mesothelioma versus pleuropulmonary synovial sarcoma: a clinicopathological study of 22 cases with molecular analysis and survival data

Sonja Klebe; Sarita Prabhakaran; Ashleigh Hocking; Emily Pulford; Sarah Moore; Mario Nicola; Philip W Allen; Douglas W Henderson

doi:10.1016/j.pathol.2018.06.001

Pleural malignant mesothelioma versus pleuropulmonary synovial sarcoma: a clinicopathological study of 22 cases with molecular analysis and survival data

Pathology. 2018 Oct;50(6):629-634. doi: 10.1016/j.pathol.2018.06.001. Epub 2018 Aug 28.

Authors

Sonja Klebe¹, Sarita Prabhakaran², Ashleigh Hocking², Emily Pulford², Sarah Moore³, Mario Nicola³, Philip W Allen⁴, Douglas W Henderson²

Affiliations

¹ Department of Anatomical Pathology, Flinders University, SA, Australia; SA Pathology Department of Surgical Pathology, Flinders Medical Centre, Bedford Park, SA, Australia. Electronic address: sonja.klebe@sa.gov.au.
² Department of Anatomical Pathology, Flinders University, SA, Australia.
³ SA Pathology Department of Molecular Pathology, Adelaide, SA, Australia.
⁴ SA Pathology Department of Surgical Pathology, Flinders Medical Centre, Bedford Park, SA, Australia.

PMID: 30170702
DOI: 10.1016/j.pathol.2018.06.001

Abstract

The aim of this study was to carry out a comparative analysis by transducin-like enhancer of split 1 (TLE1) immunohistochemistry and molecular analysis of SYT-SSX, for 16 pleural predominantly sarcomatoid mesotheliomas and six cases of pleuropulmonary synovial sarcoma (five pleural in distribution only, with one case of a predominantly subpleural upper lobe synovial sarcoma), all of which were solely or predominantly monophasic. Our comparison included survival and some clinical data. We consider that the following points emerged from this study.

Keywords: FISH; Pleura; RT-PCR; TLE1; age; biphasic; mesothelioma; monophasic; sarcoma; sarcomatoid; survival; synovial; t(X;18).

MeSH terms

Aged
Aged, 80 and over
Biomarkers, Tumor / analysis*
Co-Repressor Proteins
Diagnosis, Differential
Female
Humans
Lung Neoplasms / diagnosis*
Male
Mesothelioma / diagnosis*
Mesothelioma, Malignant
Middle Aged
Oncogene Proteins, Fusion / analysis
Oncogene Proteins, Fusion / biosynthesis
Pleural Neoplasms / diagnosis*
Repressor Proteins / analysis
Repressor Proteins / biosynthesis
Sarcoma, Synovial / diagnosis*

Substances

Biomarkers, Tumor
Co-Repressor Proteins
Oncogene Proteins, Fusion
Repressor Proteins
SYT-SSX fusion protein
TLE1 protein, human