Objective: To investigate the relationship of the levels of serum androgens with lipid metabolism in middle-aged and elderly men in Zunyi, Guizhou.
Methods: Using the stratified cluster sampling method, we conducted a questionnaire investigation and physical examinations among 437 men in Zunyi City. We divided the subjects into a middle-aged (40－64 ［53.20 ± 7.41］ years, n = 269) and an elderly group (=≥65 ［70.63 ± 4.66］ years, n = 168) and collected fasting elbow venous blood samples from them for measuring the levels of total testosterone (TT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), total cholesterol (TCH), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), calculated free testosterone (cFT), free testosterone index (FTI), and testosterone secretion index (TSI).
Results: Compared with the elderly group, the middle-aged males showed significantly lower SHBG, LH, HDL and LDL, and higher cFT, FTI, TSI, TG and TCH (all P < 0.05). TT and SHBG were negatively correlated with TG, TCH, HDL and LDL, while cFT was positively correlated with TCH, and so was FTI with TG, TCH with LDL, and TSI with TCH, HDL and LDL (all P < 0.05), but LH was negatively correlated with TG, TCH and LDL (all P < 0.05). Multivariate linear regression analysis showed that TT and SHBG were negatively correlated with TG, TCH, HDL and LDL, and so was LH with TCH, HDL and LDL (all P < 0.05).
Conclusions: In the middle-aged and elderly men in Zunyi, low concentrations of TT, SHBG and LH were associated with the increased risk of high-TCH and -LDL dyslipidemia, low concentrations of TT and SHBG with that of high-TG dyslipidemia, while high concentrations of TT, SHBG and LH with that of low-HDL dyslipidemia.
目的： 探究贵州遵义市中老年男性血清雄激素水平与血脂代谢的关系。方法： 采用分层整群抽样方法在遵义市抽取437例年龄=≥40岁的男性行问卷调查和体格检查，采集空腹肘静脉血样标本检测血清总睾酮（TT）、性激素结合球蛋白（SHBG）、黄体生成素（LH）、总胆固醇（TCH）、甘油三脂（TG）、高密度脂蛋白（HDL）和低密度脂蛋白（LDL），计算游离睾酮（FT）、游离睾酮指数（FTI）和睾酮分泌指数（TSI）。结果： 中年组SHBG、LH、HDL和LDL均低于老年组，FT、FTI、TSI高于老年组(P均<0.05)。TT和SHBG与TG、TCH、HDL和LDL呈负相关，FT与TCH呈正相关，FTI与TG、TCH和LDL呈正相关，TSI与TCH、HDL和LDL呈正相关，LH与TG、TCH和LDL呈负相关(P均<0.05)。多元线性回归分析显示TT和SHBG与TG、TCH、HDL、LDL仍呈负相关；LH与TCH、HDL和LDL呈负相关(P均<0.05)。结论： 中老年男性血清TT、SHBG和LH降低有增加患高TC血症和高LDL血症风险，TT和SHBG降低有增加患高TG血症风险，而TT、SHBG和LH升高有增加患低HDL血症风险。.
Keywords: androgen; lipid metabolism; middle-aged and elderly men.