Molecular characterization of Coxsackievirus A16 strains isolated from children with severe hand, foot, and mouth disease in Yunnan, Southwest China, during 2009-2015

J Med Virol. 2019 Jan;91(1):155-160. doi: 10.1002/jmv.25297. Epub 2018 Oct 9.

Abstract

Coxsackievirus A16 (CV-A16) commonly causes mild symptoms, but severe diseases, such as aseptic meningitis, encephalitis, and even fatal cases, have been reported. Thirteen CV-A16 strains were isolated from patients with severe hand, foot, and mouth disease in Yunnan, Southwest China, from 2009 to 2015. Subgenotype B1a and B1b of CV-A16 were predominantly circulating the region with B1b the predominant strain in recent years. The mean rate of nucleotide substitution based on the VP1 gene sequence was 4.545 × 10 -3 substitution per site per year from 2009 to 2015. These results may help in understanding the genetic diversity of CV-A16 and develop a CV-A16 vaccine.

Keywords: Coxsackievirus A16; characterization; complete genome; phylogenetic analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • China / epidemiology
  • Enterovirus / classification*
  • Enterovirus / genetics
  • Enterovirus / isolation & purification*
  • Genotype*
  • Hand, Foot and Mouth Disease / epidemiology
  • Hand, Foot and Mouth Disease / pathology*
  • Hand, Foot and Mouth Disease / virology*
  • Humans
  • Mutation Rate
  • Viral Structural Proteins / genetics

Substances

  • Viral Structural Proteins