Cerebrospinal fluid 5-HIAA concentrations correlate with cardiac uptake of 123I-MIBG during myocardial scintigraphy in drug naïve Parkinson's disease

Hidetomo Murakami; Ken Yamamoto; Taro Yasumoto; Atsushi Kimura; Yoshiki Sakae; Shohei Nomoto; Satomi Kubota; Daishi Watanabe; Keiko Watanabe; Yu Saito; Satoshi Yano; Kenjiro Ono

doi:10.1007/s00702-018-1917-x

Cerebrospinal fluid 5-HIAA concentrations correlate with cardiac uptake of ¹²³I-MIBG during myocardial scintigraphy in drug naïve Parkinson's disease

J Neural Transm (Vienna). 2018 Oct;125(10):1511-1514. doi: 10.1007/s00702-018-1917-x. Epub 2018 Aug 23.

Authors

Affiliations

¹ Department of Neurology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan.
² Department of Neurology, School of Medicine, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8666, Japan. onoken@med.showa-u.ac.jp.

PMID: 30167932
DOI: 10.1007/s00702-018-1917-x

Abstract

We examined the correlations between cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) and imaging assessment scores, using ¹²³I-Ioflupane SPECT and ¹²³I-MIBG myocardial scintigraphy in 23 drug naïve PD patients. The CSF 5-HIAA concentration correlated with the H/M ratio of the delayed image (r = 0.458, p < 0.05) and the washout rate (r = - 0.642, p < 0.01) of ¹²³I-MIBG myocardial scintigraphy. These correlations suggest some unclarified pathophysiological links between the central serotonergic and cardiac sympathetic systems.

Keywords: 123I-meta-iodobenzylguanidine myocardial scintigraphy; 5-Hydroxyindoleacetic acid; Biomarker; Cerebrospinal fluid; Lewy body; Parkinson’s disease.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

3-Iodobenzylguanidine / pharmacokinetics*
Aged
Aged, 80 and over
Autonomic Fibers, Postganglionic / metabolism
Biomarkers
Cognitive Dysfunction / etiology
Dementia / etiology
Female
Heart Conduction System / physiopathology
Homovanillic Acid / cerebrospinal fluid
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Iodine Radioisotopes / pharmacokinetics*
Male
Middle Aged
Myocardial Perfusion Imaging*
Myocardium / metabolism*
Nortropanes / pharmacokinetics*
Organ Specificity
Parkinson Disease / cerebrospinal fluid
Parkinson Disease / metabolism*
Parkinson Disease / psychology
Radiopharmaceuticals / pharmacokinetics*
Serotonin / metabolism
Tomography, Emission-Computed, Single-Photon*

Substances

Biomarkers
Iodine Radioisotopes
Nortropanes
Radiopharmaceuticals
Serotonin
3-Iodobenzylguanidine
Hydroxyindoleacetic Acid
Iodine-123
ioflupane
Homovanillic Acid