Five New Diterpenoids from the Seeds of Euphorbia lathyris

Chem Biodivers. 2018 Nov;15(11):e1800386. doi: 10.1002/cbdv.201800386. Epub 2018 Oct 31.

Abstract

A new premyrsinane-type diterpenoid, premylanin (1), and four new lathyrane-type diterpenoids named Euphorbia Factors L30 -L33 (2-5) were isolated from the seeds of Euphorbia lathyris, together with thirteen known ones (6-18). Their structures were elucidated through spectroscopic analyses, including IR, UV, HR-ESI-MS, 1D- and 2D-NMR. The cytotoxicities of compounds 1-4 and 6-18 against HCT116, MCF-7, 786-0, HepG2 cell lines were evaluated, and compound 13 exhibited considerable cytotoxic activities with an IC50 values of 6.44, 8.43, 15.3, 9.32 μm, respectively.

Keywords: Euphorbia Factors L30-L33; Euphorbia lathyris; cytotoxicity; diterpenoids; natural products; premylanin.

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Euphorbia / chemistry*
  • Humans
  • Molecular Structure
  • Seeds / chemistry*
  • Structure-Activity Relationship
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Diterpenes