Objective: To investigate the prevalence of Ureaplasma urealyticum (UU) infection in infertile men, its influence on routine semen parameters and the distribution of antisperm antibody (AsAb) and its types in infertile patients with UU infection.
Methods: We detected the positive rate of UU infection, semen parameters, and the distribution of AsAb and its types in 662 infertile men and 25 normal fertile male controls followed by comparison of the obtained data between the two groups of subjects.
Results: The positive rate of UU infection was significantly higher in the infertile men than in the normal controls (52.87% ［350/662］ vs 16.00% ［4/25］, χ2 = 11.68, P <0.05). The semen volume, sperm count, sperm concentration and percentage of progressively motile sperm were remarkably lower in the UU-positive infertile males than in the control group (P <0.05). No statistically significant difference was observed between the UU-positive and UU-negative groups in the positive rates of total AsAb (43.4% vs 36.5%, χ2 = 3.25, P >0.05) and AsAb IgA, IgM and IgG in the seminal plasma, or in the percentages of serum AsAb IgM (16.9% vs 20.5%, χ2 = 1.22, P >0.05) and IgG (32.7% vs 28.9%, χ2 = 0.99, P >0.05) except in that of serum AsAb IgA (23.6% vs 17.0%, χ2 = 4.03, P <0.05).
Conclusions: The UU infection rate is high in infertile males, which decreases the semen volume, total sperm count, motile sperm concentration and percentage of progressively motile sperm and increases the positive rate of serum AsAb IgA.
目的： 了解不育男性解脲脲原体（UU）的感染率，分析UU感染对常规精液参数的影响；探讨不育男性合并UU感染者抗精子抗体（AsAb）及其不同类型的分布。方法： 选取2016年4~11月就诊的男性不育患者662例，25例生育者为对照组，检测UU、精子质量参数和AsAb及其类型的分布情况。结果： 不育组（阳性率52.87%，350/662）较对照组（阳性率16.00%，4/25）UU感染率明显增高（χ2=11.68，P<0.05）。UU阳性不育组患者，精液量、精子总数、活动精子浓度、前向运动精子百分率，较对照组均明显减低（P均<0.05）。UU阳性不育组患者精浆总AsAb阳性率为43.4%，比UU阴性不育组的36.5%虽有所升高，但差异没有统计学意义（χ2=3.25，P>0.05）。UU阳性不育组精浆AsAb-IgA、AsAb-IgM、AsAb-IgG，与UU阴性不育组相比差异没有统计学意义。UU阳性不育组血清AsAb-IgA、AsAb-IgM、AsAb-IgG阳性率分别为23.6%、16.9%、32.7%，UU阴性不育组血清AsAb-IgA、AsAb-IgM、AsAb-IgG阳性率分别为17.0%、20.5%、28.9%， AsAb-IgM、AsAb-IgG无显著性差异，但UU阳性组AsAb-IgA的阳性率明显增高（χ2IgA=4.03，P<0.05；χ2IgM=1.22，χ2IgG=0.99，P>0.05）。结论： 男性不育患者UU的感染率更高，UU感染者精液量、精子总数、活动精子浓度、前向运动精子百分率显著降低，并导致血清AsAb-IgA阳性率升高。.
Keywords: IgA; IgG; IgM; Ureaplasma urealyticum; antisperm antibody; semen parameter; male infertility.