Composite Hydrogel Embedded with Porous Microspheres for Long-Term pH-Sensitive Drug Delivery

Tissue Eng Part A. 2019 Feb;25(3-4):172-182. doi: 10.1089/ten.TEA.2018.0071. Epub 2018 Nov 20.

Abstract

A composite hydrogel embedded with porous microspheres fabricated by phase separation methods was developed and showed excellent long-term anticancer drug delivery capability to cancer cells.

Keywords: cancer; drug delivery; hydrogel; osteosarcoma; porous microspheres.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacokinetics
  • Antineoplastic Agents* / pharmacology
  • Cell Line, Tumor
  • Humans
  • Hydrogels* / chemistry
  • Hydrogels* / pharmacology
  • Microspheres*
  • Osteonecrosis / drug therapy*
  • Osteonecrosis / metabolism
  • Osteonecrosis / pathology
  • Osteosarcoma / drug therapy*
  • Osteosarcoma / metabolism
  • Osteosarcoma / pathology
  • Porosity

Substances

  • Antineoplastic Agents
  • Hydrogels