Adenovirus Type 21 Outbreak Among Lung Transplant Patients at a Large Tertiary Care Hospital

Sarah E Philo; Benjamin D Anderson; Sylvia F Costa; Nancy Henshaw; Sarah S Lewis; John M Reynolds; Jayanthi Jayakumar; Yvonne C F Su; Gregory C Gray

doi:10.1093/ofid/ofy188

Adenovirus Type 21 Outbreak Among Lung Transplant Patients at a Large Tertiary Care Hospital

Open Forum Infect Dis. 2018 Jul 31;5(8):ofy188. doi: 10.1093/ofid/ofy188. eCollection 2018 Aug.

Authors

Sarah E Philo^{1

2}, Benjamin D Anderson^{1

2

3}, Sylvia F Costa¹, Nancy Henshaw⁴, Sarah S Lewis¹, John M Reynolds⁵, Jayanthi Jayakumar⁶, Yvonne C F Su⁶, Gregory C Gray^{1

2

3

6}

Affiliations

¹ Division of Infectious Disease, School of Medicine, Duke University, Durham, North Carolina.
² Duke Global Health Institute, Duke University, Durham, North Carolina.
³ Global Health Research Center, Duke Kunshan University, Kunshan, China.
⁴ Department of Pathology, School of Medicine, Duke University, Durham, North Carolina.
⁵ Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Hospital, Durham, North Carolina.
⁶ Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.

Abstract

Here we summarize an April 2016, 7-patient cluster of human adenovirus (HAdV) infections in a cardiothoracic surgery intensive care unit. We show that the patients were infected with a single HAdV21b type. Rapid HAdV typing diagnostics and effective antiviral interventions are needed for immunocompromised patients suffering from HAdV infections.

Keywords: adenovirus; epidemiology; lung transplant; outbreak.