[Up to date of pathophysiology mechanism of idiopathic nephrotic syndromes: Minimal change disease and focal and segmental glomerulosclerosis]

Abstract

Idiopathic nephrotic syndrome represents up to 30% of adult glomerulopathies. However, its prognosis according to remission, relapse and renal failure remains unchanged since the 80s and prediction remains difficult. Physiopathology of adult idiopathic nephrotic syndrome is complex and multifactorial, including immunologic and environmental factors and a putative permeability-circulating factor, still unknown. In this point of view, we propose to summarize actual knowledge about idiopathic minimal change disease and focal and segmental glomerulosclerosis physiopathology.

Keywords: Circulating permeability factor; Facteur circulant de perméabilité; Focal and segmental glomerulosclerosis; Hyalinose segmentaire et focale; Idiopathic nephrotic syndrome; Lymphocyte; Lésions glomérulaires minimes; Minimal change disease; Podocyte; Syndrome néphrotique idiopathique.