Magnetic resonance imaging based radiomics signature for the preoperative discrimination of stage I-II and III-IV head and neck squamous cell carcinoma

Jiliang Ren; Jie Tian; Ying Yuan; Di Dong; Xiaoxia Li; Yiqian Shi; Xiaofeng Tao

doi:10.1016/j.ejrad.2018.07.002

Magnetic resonance imaging based radiomics signature for the preoperative discrimination of stage I-II and III-IV head and neck squamous cell carcinoma

Eur J Radiol. 2018 Sep:106:1-6. doi: 10.1016/j.ejrad.2018.07.002. Epub 2018 Jul 4.

Authors

Jiliang Ren¹, Jie Tian², Ying Yuan¹, Di Dong², Xiaoxia Li¹, Yiqian Shi¹, Xiaofeng Tao³

Affiliations

¹ Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
² Key Laboratory of Molecular Imaging, Chinese Academy of Science, Beijing, 100190, China.
³ Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. Electronic address: cjr.taoxiaofeng@vip.163.com.

PMID: 30150029
DOI: 10.1016/j.ejrad.2018.07.002

Abstract

Purpose: This study aimed to investigate the predictive ability of magnetic resonance imaging (MRI) based radiomics signature for the preoperative staging in HNSCC.

Methods: This study involved127 consecutive patients (training cohort: n = 85; testing cohort, n = 42) with stage I-IV HNSCC. A total of 970 radiomics features were extracted from T2-weighted (T2W) (n = 485) and contrast-enhanced T1-weighted (ceT1W) (n = 485) MRI for each case. Radiomics signatures were constructed with least absolute shrinkage and selection operator (LASSO) logistic regression. Associations between radiomics signatures and HNSCC staging were explored. Areas under the receiver operating characteristic curve (AUC) and classification performance of radiomics signatures were determined and compared with those of the visual assessment.

Results: Ten features from T2W images, six from ceT1W images, and six from combined T2W and ceT1W images were selected by LASSO logistic regression. The three radiomics signatures of stage III-IV HNSCC were significantly higher than that for stage I-II in both cohorts (all P < 0.05). The radiomics signatures from ceT1W and combined images performed well in the discrimination of stage I-II and III-IV HNSCC, with AUCs of 0.828 and 0.850 in the training cohort, and AUCs of 0.853 and 0.849 in the testing cohort. Based on the cut-off value of the training cohort, the radiomics signature from combined images achieved best classification performance in both cohorts, with accuracies of 0.788 and 0.857, sensitivities of 0.836 and 0.885, and specificities of 0.700 and 0.813. Significant differences in accuracy and sensitivity were found between the radiomics signature from combined images and the visual assessment of the radiologists in the training cohort.

Conclusion: Radiomics signature based on MRI could discriminate stage I-II from stage III-IV HNSCC, which may serve as a complementary tool for preoperative staging.

Keywords: Head and neck cancer; Magnetic resonance imaging; Predictor; Radiomics signature; Stage.

MeSH terms

Aged
Area Under Curve
Female
Humans
Image Enhancement / methods*
Logistic Models
Magnetic Resonance Imaging* / methods
Male
Middle Aged
Neoplasm Staging / methods*
Predictive Value of Tests
Preoperative Care*
ROC Curve
Retrospective Studies
Sensitivity and Specificity
Squamous Cell Carcinoma of Head and Neck / diagnostic imaging*
Squamous Cell Carcinoma of Head and Neck / pathology