Emergence of carbapenem-resistant Acinetobacter pittii carrying the blaOXA-72 gene in the Amazon region, Brazil

Diagn Microbiol Infect Dis. 2019 Jan;93(1):82-84. doi: 10.1016/j.diagmicrobio.2018.07.017. Epub 2018 Aug 1.

Abstract

We sought to characterize the genetic context of blaOXA-72 gene in a carbapenem-resistant Acinetobacter pittii strain recovered from a hospitalized patient from Belém, North Brazil, in the Amazon region. We found that the blaOXA-72 gene was carried by a small plasmid, pIEC338SCox, that is 10,498 bp. The gene is flanked by XerC/XerD-like recombinase sites, which suggests that this gene was acquired onto this plasmid by recombination.

Keywords: A. pittii; Carbapenem-resistant; OXA-72; Plasmid.

MeSH terms

  • Acinetobacter / classification
  • Acinetobacter / drug effects*
  • Acinetobacter / genetics*
  • Acinetobacter / isolation & purification
  • Acinetobacter Infections / microbiology*
  • Aged
  • Anti-Bacterial Agents / pharmacology*
  • Brazil
  • Carbapenems / pharmacology*
  • DNA, Bacterial / genetics
  • Drug Resistance, Multiple, Bacterial / drug effects
  • Drug Resistance, Multiple, Bacterial / genetics*
  • Female
  • Genes, Bacterial / genetics*
  • Genome, Bacterial / genetics
  • Humans
  • Microbial Sensitivity Tests
  • Plasmids / genetics
  • Pneumonia, Ventilator-Associated / microbiology
  • Recombination, Genetic
  • Sequence Analysis, DNA

Substances

  • Anti-Bacterial Agents
  • Carbapenems
  • DNA, Bacterial