Toxicology of Frequently Encountered Nonsteroidal Anti-inflammatory Drugs in Dogs and Cats: An Update

Vet Clin North Am Small Anim Pract. 2018 Nov;48(6):969-984. doi: 10.1016/j.cvsm.2018.06.003. Epub 2018 Aug 24.

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are used for their antipyretic, anti-inflammatory, and analgesic properties. Although most NSAIDs consist of a range of pharmacologically active agents with diverse chemical structures and properties, they have similar therapeutic and adverse effects associated with their use. Each year, the American Society for the Prevention of Cruelty to Animals Animal Poison Control Center (APCC) receives hundreds of cases involving acute accidental ingestion/overdose of NSAIDs in dogs and cats. This article provides an overview on the classification, uses, pharmacokinetics, mechanisms of action, and treatment of the most commonly encountered NSAIDs in dogs and cats.

Keywords: Cats; Dogs; Incidents; Nonsteroidal anti-inflammatory drugs; Toxicology; Treatment.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics
  • Anti-Inflammatory Agents, Non-Steroidal / toxicity*
  • Cat Diseases / chemically induced*
  • Cat Diseases / drug therapy
  • Cat Diseases / physiopathology
  • Cats
  • Dog Diseases / chemically induced*
  • Dog Diseases / drug therapy
  • Dog Diseases / physiopathology
  • Dogs

Substances

  • Anti-Inflammatory Agents, Non-Steroidal