Neonatal cholelithiasis in Down syndrome: Is hypothyroidism involved? A case-report

J Neonatal Perinatal Med. 2018;11(4):423-425. doi: 10.3233/NPM-181.

Abstract

We report a 3-month-old male with Down syndrome (DS), prolonged jaundice and poor weight gain, that showed biliary lithiasis and undiagnosed congenital hypothyroidism (CH).CH should be considered in DS, especially in presence of gastrointestinal symptoms or malformations. Clinicians should be aware of the increased risk of gallstones in hypothyroid children with DS, even in neonatal age.

Keywords: Cholelithiasis; Down syndrome; congenital hypothyroidism.

Publication types

  • Case Reports

MeSH terms

  • Bile Ducts / abnormalities
  • Bile Ducts / diagnostic imaging*
  • Cholagogues and Choleretics / therapeutic use*
  • Cholelithiasis / diagnostic imaging
  • Cholelithiasis / drug therapy*
  • Cholelithiasis / etiology
  • Cholelithiasis / physiopathology
  • Down Syndrome / complications
  • Down Syndrome / physiopathology*
  • Gallbladder / diagnostic imaging*
  • Humans
  • Hypothyroidism / drug therapy
  • Hypothyroidism / etiology
  • Hypothyroidism / physiopathology*
  • Infant
  • Male
  • Treatment Outcome
  • Ultrasonography
  • Ursodeoxycholic Acid / therapeutic use*

Substances

  • Cholagogues and Choleretics
  • Ursodeoxycholic Acid