Tremor during orthostatism as the initial symptom of Machado-Joseph disease

Shinichi Shirai; Ichiro Yabe; Ryoji Naganuma; Chika Sato; Ikuko Takahashi; Masaaki Matsushima; Takahiro Kano; Hidenao Sasaki

doi:10.1016/j.clineuro.2018.08.009

Tremor during orthostatism as the initial symptom of Machado-Joseph disease

Clin Neurol Neurosurg. 2018 Oct:173:173-175. doi: 10.1016/j.clineuro.2018.08.009. Epub 2018 Aug 10.

Authors

Shinichi Shirai¹, Ichiro Yabe², Ryoji Naganuma³, Chika Sato³, Ikuko Takahashi³, Masaaki Matsushima³, Takahiro Kano³, Hidenao Sasaki³

Affiliations

¹ Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. Electronic address: shirai@med.hokudai.ac.jp.
² Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. Electronic address: yabe@med.hokudai.ac.jp.
³ Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

PMID: 30149304
DOI: 10.1016/j.clineuro.2018.08.009

Abstract

A 60-year-old man was admitted to our hospital. He had mild tremor in his four extremities when supine or sitting, which was markedly exacerbated when standing. We diagnosed him with Machado-Joseph disease according to the genetic test. His tremor improved with clonazepam, trihexyphenidyl, and a rotigotine patch.

Keywords: Machado-Joseph disease; Orthostatic tremor; Tremor during orthostatism.

Publication types

Case Reports

MeSH terms

Clonazepam / therapeutic use*
Electromyography / methods
Humans
Machado-Joseph Disease / drug therapy*
Machado-Joseph Disease / genetics
Male
Middle Aged
Pedigree
Treatment Outcome
Tremor / drug therapy*
Tremor / genetics
Trihexyphenidyl / therapeutic use*

Substances

Clonazepam
Trihexyphenidyl