Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration

Jen-Yang Tang; Fu Ou-Yang; Ming-Feng Hou; Hurng-Wern Huang; Hui-Ru Wang; Kun-Tzu Li; Sundas Fayyaz; Chih-Wen Shu; Hsueh-Wei Chang

doi:10.1016/j.semcancer.2018.08.010

Oxidative stress-modulating drugs have preferential anticancer effects - involving the regulation of apoptosis, DNA damage, endoplasmic reticulum stress, autophagy, metabolism, and migration

Semin Cancer Biol. 2019 Oct:58:109-117. doi: 10.1016/j.semcancer.2018.08.010. Epub 2018 Aug 24.

Authors

Jen-Yang Tang¹, Fu Ou-Yang², Ming-Feng Hou³, Hurng-Wern Huang⁴, Hui-Ru Wang⁵, Kun-Tzu Li⁶, Sundas Fayyaz⁷, Chih-Wen Shu⁸, Hsueh-Wei Chang⁹

Affiliations

¹ Department of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Radiation Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address: reyata@kmu.edu.tw.
² Division of Breast Surgery and Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address: swfuon@kmu.edu.tw.
³ Division of Breast Surgery and Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: mifeho@kmu.edu.tw.
⁴ Institute of Biomedical Science, National Sun Yat-sen University, Kaohsiung, Taiwan. Electronic address: sting@mail.nsysu.edu.tw.
⁵ Institute of Biomedical Science, National Sun Yat-sen University, Kaohsiung, Taiwan. Electronic address: hr_wang@g-mail.nsysu.edu.tw.
⁶ Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: ed109552@edah.org.tw.
⁷ Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College (RLMC), Lahore, Pakistan. Electronic address: sundas.khan23@yahoo.com.
⁸ School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan. Electronic address: cwshu@isu.edu.tw.
⁹ Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung, Taiwan; Center for Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: changhw@kmu.edu.tw.

PMID: 30149066
DOI: 10.1016/j.semcancer.2018.08.010

Abstract

To achieve preferential effects against cancer cells but less damage to normal cells is one of the main challenges of cancer research. In this review, we explore the roles and relationships of oxidative stress-mediated apoptosis, DNA damage, ER stress, autophagy, metabolism, and migration of ROS-modulating anticancer drugs. Understanding preferential anticancer effects in more detail will improve chemotherapeutic approaches that are based on ROS-modulating drugs in cancer treatments.

Keywords: Anticancer drugs; Function; Oxidative stress; Preferential killing; Redox homeostasis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Antineoplastic Agents / pharmacology*
Antineoplastic Agents / therapeutic use*
Autophagy / drug effects*
Cell Movement / drug effects*
DNA Damage / drug effects*
Endoplasmic Reticulum Stress / drug effects*
Humans
Oxidative Stress / drug effects*

Substances

Antineoplastic Agents