Prenatal diagnosis of a rare de novo 1q22-q25.1 chromosomal deletion syndrome using oligo array CGH

Gholamreza Shariati; Alihossein Saberi; Mohammad Hamid; Hamid Galehdari; Alireza Sedaghat; Nehzat Abdorasuli

doi:10.1002/ccr3.1604

Prenatal diagnosis of a rare de novo 1q22-q25.1 chromosomal deletion syndrome using oligo array CGH

Clin Case Rep. 2018 Jun 13;6(8):1464-1469. doi: 10.1002/ccr3.1604. eCollection 2018 Aug.

Authors

Gholamreza Shariati^{1

2}, Alihossein Saberi^{1

2}, Mohammad Hamid^{1

3}, Hamid Galehdari^{1

4}, Alireza Sedaghat⁵, Nehzat Abdorasuli²

Affiliations

¹ Department of Medical Genetics Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran.
² Narges Genetics Lab. Ahvaz Iran.
³ Department of Molecular Medicine Biotechnolgy Section Pasteur Institute of Iran Tehran Iran.
⁴ Department of Genetics Faculty of Sciences Shahid Chamran University of Ahvaz Ahvaz Iran.
⁵ Diabetic Research Center Ahvaz Jundishpur University of Medical Sciences Ahvaz Iran.

Abstract

We present prenatal diagnosis of a case with a rare de novo interstitial deletion of 1q21-q25.1 by oligo array CGH and provide detailed information on unbalanced gene content and the breakpoints. The affected fetus was delivered at 37 weeks' gestation with a unique clinical phenotype.

Keywords: 1q22‐q25.1; cleft lip/palate; oligo array CGH; small hands and feet.

Publication types

Case Reports