Pogostemins A-C, three new cytotoxic meroterpenoids from Pogostemon auricularius

Fitoterapia. 2018 Oct:130:100-104. doi: 10.1016/j.fitote.2018.08.015. Epub 2018 Aug 23.

Abstract

Pogostemins A-C (1-3), three new meroterpenoids with pyrone-sesquiterpenoid hybrid skeletons, were isolated from the aerial parts of Pogostemon auricularius. Their chemical structures were elucidated by 1D- and 2D-NMR and HRESIMS analyses. Compound 1 showed significant cytotoxicities against the human colon adenocarcinoma SW-480, epidermoid carcinoma KB, gastric cancer AGS, hepatoma cancer Hep-G2, and lung cancer LU-1 cell lines with IC50 values of 7.21, 8.49, 9.44, 11.75, and 12.76 μg/mL, respectively.

Keywords: Lamiaceae; Pogostemon auricularius; cytotoxicity; pogostemins A-C.

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Humans
  • Molecular Structure
  • Phytochemicals / isolation & purification*
  • Phytochemicals / pharmacology
  • Plant Leaves / chemistry
  • Plants, Medicinal / chemistry
  • Pogostemon / chemistry*
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology
  • Vietnam

Substances

  • Antineoplastic Agents, Phytogenic
  • Phytochemicals
  • Terpenes