The Gut Microbiome in Pancreatic Disease

Abstract

The gut microbiome increasingly is recognized for its role in human health and disease. Initial evidence has indicated that gut microbial dysbiosis is associated with several pancreatic diseases. Although it is not known if these associations are causative, gut dysbiosis is hypothesized to mediate chronic proinflammatory changes in the pancreas. Further mechanistic and epidemiologic studies of the microbiome are needed. Ultimately, targeted modulation of the microbiota could have therapeutic value.

Keywords: Dysbiosis; Intratumoral Bacteria; Microbiome; Pancreatic Cancer; Pancreatitis; Probiotics.