Chitosan based hydrogels and their applications for drug delivery in wound dressings: A review

Carbohydr Polym. 2018 Nov 1:199:445-460. doi: 10.1016/j.carbpol.2018.06.114. Epub 2018 Jun 28.

Abstract

Advanced development of chitosan hydrogels has led to new drug delivery systems that can release their active ingredients in response to environmental stimuli. This review considers more recent investigation of chitosan hydrogel preparations and the application of these preparations for drug delivery in wound dressings. Applications and structural characteristics of different types of active ingredients, such as growth factors, nanoparticles, nanostructures, and drug loaded chitosan hydrogels are summarized.

Keywords: Chitosan hydrogel; Drug delivery; Growth factor; Nanoparticles; Wound dressing.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology
  • Bandages*
  • Chitosan / chemical synthesis
  • Chitosan / chemistry
  • Chitosan / pharmacology*
  • Drug Carriers / chemical synthesis
  • Drug Carriers / chemistry
  • Drug Carriers / pharmacology*
  • Drug Liberation
  • Humans
  • Hydrogels / chemical synthesis
  • Hydrogels / chemistry
  • Hydrogels / pharmacology*
  • Intercellular Signaling Peptides and Proteins / chemistry
  • Intercellular Signaling Peptides and Proteins / pharmacology
  • Nanoparticles / chemistry
  • Oils, Volatile / chemistry
  • Oils, Volatile / pharmacology
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Wound Healing / drug effects

Substances

  • Anti-Infective Agents
  • Drug Carriers
  • Hydrogels
  • Intercellular Signaling Peptides and Proteins
  • Oils, Volatile
  • Plant Extracts
  • Chitosan