PP1 Phosphatase Complexes: Undruggable No Longer

Paola Vagnarelli; Dario R Alessi

doi:10.1016/j.cell.2018.08.007

PP1 Phosphatase Complexes: Undruggable No Longer

Cell. 2018 Aug 23;174(5):1049-1051. doi: 10.1016/j.cell.2018.08.007.

Authors

Paola Vagnarelli¹, Dario R Alessi²

Affiliations

¹ College of Health and Life Science, Research Institute for Environment Health and Society, Brunel University London, London UB8 3PH, UK. Electronic address: paola.vagnarelli@brunel.ac.uk.
² Medical Research Council (MRC), Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK. Electronic address: d.r.alessi@dundee.ac.uk.

PMID: 30142342
DOI: 10.1016/j.cell.2018.08.007

Abstract

The identification of inhibitors targeting regulatory subunits of serine/threonine PP1 phosphatases reported by Krzyzosiak et al. is a significant step in expanding the pharmacological regulation of phosphorylation beyond kinases. The selective inhibitor of the R15B phosphatase regulatory subunit, termed Raphin1, protects cells from stress and delays neurodegeneration in a mouse model of Huntington's disease.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Mice
Phosphorylation
Protein Phosphatase 1

Substances

Ppp1r15b protein, mouse
Protein Phosphatase 1

Abstract

Publication types

MeSH terms

Substances

Grants and funding