Mycosis Fungoides

Excerpt

Primary cutaneous lymphomas are the second most common extranodal non-Hodgkin Lymphomas. They may be of either T cell, B cell, or NK cell origin. Cutaneous T Cell lymphomas (CTCL) comprise a group of heterogeneous lymphomas which clinically differ from systemic lymphomas, even though they might show similar histology.

Mycosis fungoides is the most common type of CTCL. It is a cutaneous lymphoma that originates in the peripheral epidermotropic T-cells, specifically the memory T-cells (CD45RO+), which express the T-cell receptor (TCR) and CD4+ immunophenotype.