Recent evidence highlights health disparities among rural communities. The purpose of this study was to learn from members of 2 Appalachia communities in North Carolina about barriers to health and well-being. Researchers conducted 3 focus groups (n = 24), which were coded and analyzed by a team of researchers to identify themes. Researchers identified 5 themes: (1) poverty/lack of economic opportunity; (2) access to health care and health resources; (3) social/mental health challenges; (4) food insecurity/hunger; and (5) youth/older adults being most vulnerable to health disparities. Ample evidence suggests that rural Appalachia is in dire need of public health attention.