Monitoring of somatic parameters at outpatient departments for mood and anxiety disorders

PLoS One. 2018 Aug 21;13(8):e0200520. doi: 10.1371/journal.pone.0200520. eCollection 2018.

Abstract

Introduction: Somatic complications account for the majority of the 13-30 years shortened life expectancy in psychiatric patients compared to the general population. The study aim was to assess to which extent patients visiting outpatient departments for mood and anxiety disorders were monitored for relevant somatic comorbidities and (adverse) effects of psychotropic drugs-more specifically a) metabolic parameters, b) lithium safety and c) ECGs-during their treatment.

Methods: We performed a retrospective clinical records review and cross-sectional analysis to assess the extent of somatic monitoring at four outpatient departments for mood and anxiety disorders in The Netherlands. We consecutively recruited adult patients visiting a participating outpatient department between March and November 2014. The primary outcome was percentage of patients without monitoring measurements. Secondary outcomes were number of measurements per parameter per patient per year and time from start of treatment to first measurement.

Results: We included 324 outpatients, of whom 60.2% were female. Most patients were treated for depressive disorders (39.8%), anxiety disorders (16.7%) or bipolar or related disorders (11.7%) and 198 patients (61.1%) used at least one psychotropic drug. For 186 patients (57.4%), no monitoring records were recorded (median treatment period 7.3 months, range 0-55.6). The median number of measurements per parameter per year since the start of outpatient treatment for patients with monitoring measurements was 0.31 (range 0.0-12.9). The median time to first monitoring measurement per parameter for patients with monitoring measurements was 3.8 months (range 0.0-50.7).

Discussion: Somatic monitoring in outpatients with mood and anxiety disorders is not routine clinical practice. Monitoring practices need to be improved to prevent psychiatric outpatients from undetected somatic complications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anxiety Disorders / drug therapy
  • Anxiety Disorders / physiopathology*
  • Anxiety Disorders / psychology
  • Comorbidity
  • Cross-Sectional Studies
  • Depressive Disorder / drug therapy
  • Depressive Disorder / physiopathology*
  • Depressive Disorder / psychology
  • Female
  • Humans
  • Male
  • Monitoring, Physiologic*
  • Mood Disorders / drug therapy
  • Mood Disorders / physiopathology*
  • Mood Disorders / psychology
  • Netherlands
  • Outpatients / psychology
  • Outpatients / statistics & numerical data*
  • Psychotropic Drugs / administration & dosage*
  • Retrospective Studies

Substances

  • Psychotropic Drugs

Grants and funding

The author(s) received no specific funding for this work, but HGR is supported by a Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)/ZonMW VENI-Grant (https://www.zonmw.nl/en/research-and-results/fundamental-research/programmas/programme-detail/veni/), grant number #016.126.059. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.