Discrepancies in fosfomycin susceptibility testing of KPC-producing Klebsiella pneumoniae with various commercial methods

Diagn Microbiol Infect Dis. 2019 Jan;93(1):74-76. doi: 10.1016/j.diagmicrobio.2018.07.014. Epub 2018 Jul 31.

Abstract

Fosfomycin susceptibility testing with Sensititre, Vitek2, Etest, Mic Strip Test and disk diffusion methodologies was compared versus reference agar dilution method (AD) with 78 clinical isolates of KPC-producing Klebsiella pneumoniae. All methodologies showed a Categorical Agreement and Essential Agreement of ≤69% and ≤72%, respectively, revealing a very low concordance with AD.

Keywords: Agar dilution; CPE; CRE; Fosfomycin-resistance; KPC-KP.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / analysis
  • Bacterial Proteins / metabolism*
  • Diagnostic Errors
  • Drug Resistance, Bacterial / drug effects
  • Fosfomycin / pharmacology*
  • Humans
  • Klebsiella Infections / microbiology
  • Klebsiella pneumoniae / drug effects*
  • Klebsiella pneumoniae / enzymology*
  • Klebsiella pneumoniae / isolation & purification
  • Microbial Sensitivity Tests / methods*
  • Microbial Sensitivity Tests / statistics & numerical data
  • Reagent Kits, Diagnostic / statistics & numerical data
  • beta-Lactamases / analysis
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Reagent Kits, Diagnostic
  • Fosfomycin
  • beta-Lactamases
  • carbapenemase