Symptomatic Dengue during Pregnancy and Congenital Neurologic Malformations

Emerg Infect Dis. 2018 Sep;24(9):1748-1750. doi: 10.3201/eid2409.170361.

Abstract

Dengue virus infection during pregnancy increased the risk for any neurologic congenital anomaly in the infant by roughly 50% and for other congenital malformations of brain 4-fold. Our results show an association between dengue during pregnancy and congenital anomalies of the brain, suggesting that flaviviruses other than Zika virus are associated with such malformations.

Keywords: birth defects; congenital anomalies; dengue; dengue virus; neurologic malformations; pregnancy; vector-borne infections; viruses.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brazil / epidemiology
  • Dengue Virus
  • Dengue*
  • Female
  • Humans
  • Infant, Newborn
  • Nervous System Malformations / epidemiology*
  • Nervous System Malformations / etiology
  • Pregnancy
  • Pregnancy Complications, Infectious*
  • Pregnancy Outcome