Adnexal mass with extremely high levels of CA-125 and CA19-9 but normal Human Epididymis Protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA): Endometriosis or ovarian malignancy? A case report

Sepideh Khodaverdi; Soheila Amini-Moghaddam; Fariba Almassi Nokiani; Neda Hashemi; Robabeh Mohammad Beigi

Adnexal mass with extremely high levels of CA-125 and CA19-9 but normal Human Epididymis Protein 4 (HE4) and Risk of Ovarian Malignancy Algorithm (ROMA): Endometriosis or ovarian malignancy? A case report

Int J Reprod Biomed. 2018 Jun;16(6):413-416.

Authors

Sepideh Khodaverdi¹, Soheila Amini-Moghaddam¹, Fariba Almassi Nokiani², Neda Hashemi¹, Robabeh Mohammad Beigi¹

Affiliations

¹ Endometriosis Research Center, Department of Obstetrics and Gynecology, Iran University of Medical Sciences (IUMS), Tehran, Iran.
² Minimally Invasive Surgery Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran.

PMID: 30123870
PMCID: PMC6079310

Abstract

Background: It has been shown that Carbohydrate antigen (CA) 125 and CA 19-9 tumor markers are useful for diagnosis and follow up of ovarian carcinoma.

Case: In this case, we reported the high level of CA-125 and CA 19-9 with large right ovarian intact endometrioma and extensive involvement of omentum.

Conclusion: Human Epididymis protein (HE4) and Risk of ovarian malignancy algorithm (ROMA) can be useful in differentiation between malignancies and benign pathologies with a good sensitivity and specificity value.

Keywords: Human epididymis protein 4 (HE4); Risk of ovarian malignancy algorithm (ROMA).

Publication types

Case Reports