Therapeutic Potential of Biomedical Cell Product in DSS-Induced Inflammation in the Small Intestine of C57Bl/6J Mice

A P Lykov; O V Poveshchenko; N A Bondarenko; M A Surovtseva; I I Kim; N P Bgatova

doi:10.1007/s10517-018-4216-5

Therapeutic Potential of Biomedical Cell Product in DSS-Induced Inflammation in the Small Intestine of C57Bl/6J Mice

Bull Exp Biol Med. 2018 Aug;165(4):576-580. doi: 10.1007/s10517-018-4216-5. Epub 2018 Aug 18.

Authors

A P Lykov¹, O V Poveshchenko², N A Bondarenko², M A Surovtseva², I I Kim², N P Bgatova²

Affiliations

¹ Research Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. aplykov2@mail.ru.
² Research Institute of Clinical and Experimental Lymphology - Affiliated Branch of Federal Research Centre Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

PMID: 30121917
DOI: 10.1007/s10517-018-4216-5

Abstract

We studied the effect of intravenous administration of biomedical cell product (bone marrow mesenchymal stem cells and media conditioned by these cells) on histological picture of the small intestine in mice with DSS-induced inflammation. It was shown that biomedical cell product promoted recovery of the intestinal mucosa in DSS-induced inflammation.

Keywords: biomedical cell product; conditioned medium; dextran sulfate sodium salt; inflammatory disease of the intestinal mucosa; mesenchymal stem cells.

MeSH terms

Animals
Cells, Cultured
Culture Media, Conditioned
Dextran Sulfate / toxicity*
Inflammation / chemically induced*
Inflammation / therapy*
Intestine, Small / immunology*
Intestine, Small / pathology*
Male
Mesenchymal Stem Cells / cytology
Mesenchymal Stem Cells / physiology*
Mice
Mice, Inbred C57BL

Substances

Culture Media, Conditioned
Dextran Sulfate