A pilot study of early onset obsessive-compulsive disorder: Symptom dimensions and association analysis with polymorphisms of the serotonin transporter gene

Psychiatry Res. 2018 Oct:268:388-391. doi: 10.1016/j.psychres.2018.07.035. Epub 2018 Jul 29.

Abstract

Our aim was to introduce more homogenous phenotypes for studying genetic variations in the clinically heterogeneous obsessive compulsive disorder (OCD) beside classical case-control analysis. Symptoms were assessed with Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS), and principle component analysis of the lifetime symptom categories yielded four factors (Cleaning, Obsessive, Compulsive, Sexual). The comparison of serotonin transporter linked polymorphic region (5-HTTLPR) in 102 OCD patients and 223 controls showed an increased L-allele frequency but no difference was observed when rs25531 was included. Intronic variants of the serotonin transporter gene did not show association with either OCD, nor with the obtained factors.

Keywords: OCD; Principal component analysis; SLC6A4 promoter and intronic variants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Child
  • Female
  • Gene Frequency / genetics
  • Genetic Variation / genetics
  • Humans
  • Male
  • Obsessive-Compulsive Disorder / diagnosis
  • Obsessive-Compulsive Disorder / genetics*
  • Obsessive-Compulsive Disorder / psychology*
  • Pilot Projects
  • Polymorphism, Genetic / genetics*
  • Principal Component Analysis / methods
  • Serotonin Plasma Membrane Transport Proteins / genetics*
  • Sexual Behavior / psychology
  • Young Adult

Substances

  • SLC6A4 protein, human
  • Serotonin Plasma Membrane Transport Proteins