Association between miR-218 rs11134527 polymorphism and risk of selected types of cancer in Asian population: An updated meta-analysis of case-control studies

Abstract

Several studies inspected the relationship between miR-218 rs11134527 polymorphism and the risk of some human cancers, but the findings remains controversial. We designed an update meta-analysis aiming to validate the association between rs11134527 polymorphism of miR-218 and cancer risk. Eligible studies including 7989 cancer cases and 8761 controls were recognized by searching Web of Science, PubMed, Scopus, and Google scholar databases. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to quantitatively evaluate the association between rs11134527 variant and cancer risk. The overall results indicated no significant relationship between miR-218 rs11134527 polymorphism and cancer risk in codominant, dominant, recessive, overdominant, and allele inheritance model tested. Stratified analysis showed that rs11134527 variant significantly increased the risk of developing esophageal squamous cell carcinoma (ESCC) in heterozygous codominant (OR = 1.32, 95%CI = 1.03-1.69, p = 0.03, AG vs GG) inheritance model. In summary, the findings of this meta-analysis did not support an association between miR-218 rs11134527 polymorphism and cancer risk. Stratified analysis showed that rs11134527 variant significantly increased the risk of developing ESCC. Larger and well-designed researches are needed to estimate this association in detail.

Keywords: Cancer; Meta-analysis; MiR-218; Polymorphism; Rs11134527.