2'-O-methylation plays an important biological role in gene expression. Owing to the explosive increase in genomic sequencing data, it is necessary to develop a method for quickly and efficiently identifying whether a sequence contains the 2'-O-methylation site. As an additional method to the experimental technique, a computational method may help to identify 2'-O-methylation sites. In this study, based on the experimental 2'-O-methylation data of Homo sapiens, we proposed a support vector machine-based model to predict 2'-O-methylation sites in H. sapiens. In this model, the RNA sequences were encoded with the optimal features obtained from feature selection. In the fivefold cross-validation test, the accuracy reached 97.95%.
Keywords: 2′-O-methylation; Homo sapiens; PseKNC; RNA sequence; chemical property.