AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing

Ageing Res Rev. 2018 Nov:47:168-175. doi: 10.1016/j.arr.2018.08.002. Epub 2018 Aug 12.

Abstract

AMP-activated protein kinase (AMPK) is a pivotal regulator of some endogenous defensive molecules in various pathological processes, particularly myocardial ischemia (MI), a high risk of myocardial infarction. Thereby it is of great significance to explore the inherent mechanism between AMPK and myocardial infarction. In this review, we first introduce the structure and role of AMPK in the heart. Next, we introduce the mechanisms of AMPK in the heart; followed by the energy regulation of AMPK in MI. Lastly, the attention will be expanded to some potential directions and further perspectives. The information compiled here will be helpful for further research and drug design in the future before AMPK might be considered as a therapeutic target of MI.

Keywords: AMP-activated protein kinase; Cardiac ageing; Glucose metabolism; Mitochondrial biosynthesis; Myocardial ischemia.

Publication types

  • Review

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Aging / metabolism*
  • Aging / pathology
  • Animals
  • Glucose / metabolism
  • Humans
  • Myocardial Infarction / metabolism
  • Myocardial Infarction / pathology
  • Myocardial Infarction / prevention & control
  • Myocardial Ischemia / metabolism*
  • Myocardial Ischemia / pathology
  • Myocardial Ischemia / prevention & control*
  • Myocardial Reperfusion Injury / metabolism
  • Myocardial Reperfusion Injury / pathology
  • Myocardial Reperfusion Injury / prevention & control
  • Myocardium / metabolism*
  • Myocardium / pathology
  • Oxidative Stress / physiology

Substances

  • AMP-Activated Protein Kinases
  • Glucose