Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa

Achara Raksat; Wisanu Maneerat; Raymond J Andersen; Stephen G Pyne; Surat Laphookhieo

doi:10.1021/acs.jnatprod.8b00321

Antibacterial Prenylated Isoflavonoids from the Stems of Millettia extensa

J Nat Prod. 2018 Aug 24;81(8):1835-1840. doi: 10.1021/acs.jnatprod.8b00321. Epub 2018 Aug 14.

Authors

Achara Raksat^{1

2}, Wisanu Maneerat^{1

2}, Raymond J Andersen³, Stephen G Pyne⁴, Surat Laphookhieo^{1

2}

Affiliations

¹ Center of Chemical Innovation for Sustainability (CIS) , Mae Fah Luang University , Chiang Rai 57100 , Thailand.
² School of Science, Mae Fah Luang University , Chiang Rai 57100 , Thailand.
³ Department of Chemistry and Department of Earth, Ocean & Atmospheric Sciences , University of British Columbia , 2036 Main Mall , Vancouver , BC , Canada V6T 1Z1.
⁴ School of Chemistry , University of Wollongong , Wollongong , New South Wales 2522 , Australia.

PMID: 30106294
DOI: 10.1021/acs.jnatprod.8b00321

Abstract

The first phytochemical investigation of the stem extract of Millettia extensa resulted in the isolation and identification of six new isoflavones, millexatins A-F (1-6), together with 16 known compounds. The structures of these new compounds were determined on the basis of their spectroscopic data. Millexatin A (1) is a rare isoflavone containing three isoprenyl units on a modified A ring. Compounds 1, 6, 10, 11, and 14 displayed promising antibacterial activity with MIC values of 2-8 μg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology*
Bacteria / drug effects
Fabaceae / chemistry*
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Isoflavones / chemistry*
Isoflavones / pharmacology*
Magnetic Resonance Spectroscopy
Microbial Sensitivity Tests
Millettia / chemistry*
Molecular Structure
Plant Extracts / chemistry
Plant Extracts / pharmacology
Plant Stems / chemistry*
Prenylation

Substances

Anti-Bacterial Agents
Isoflavones
Plant Extracts