Abstract
In the present investigation, trans-chalcone and licochalcone A were tested against MCF-7 and BT-20 breast cancer cell lines for anti-tumor activity. We found that both chalcones down regulated important genes associated to cancer development and inhibited cell migration of metastatic cells (BT-20). Finally, we observed that licochalcone A reduces the MDR-1 protein, while both chalcones suppress the AURKA protein in a dose-dependent manner. In conclusion, we observed the trans-chalcone and licochalcone A affected the cell viability of breast cancer cell lines MCF-7 and BT-20 and presents anti-metastatic and anti-resistance potential, by the repression of AUKA and MDR-1 proteins.
Keywords:
BT-20; MCF-7; MDR; flavonoids; metastasis.
MeSH terms
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / antagonists & inhibitors*
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics
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ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
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Aurora Kinase A / antagonists & inhibitors*
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Aurora Kinase A / genetics
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Aurora Kinase A / metabolism
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology
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Cell Line, Tumor
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Cell Movement / drug effects
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Cell Survival / drug effects
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Chalcones / chemistry
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Chalcones / pharmacology*
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Drug Resistance, Multiple / genetics*
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Drug Resistance, Neoplasm / genetics*
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Female
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Gene Expression Profiling
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Humans
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Molecular Structure
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Neoplasm Metastasis
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Neoplasm Staging
Substances
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ATP Binding Cassette Transporter, Subfamily B, Member 1
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Chalcones
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Aurora Kinase A